Daxxify vs Botox vs Xeomin: Which Wrinkle Relaxer Lasts the Longest?

Summary Highlights:

• Daxxify lasts up to twice as long as Botox and Xeomin
• Peptide-based formulation means no human or animal byproducts
• Ideal for busy professionals seeking fewer maintenance visits
• Personalized care at Columbine Aesthetics ensures safe, natural results

When it comes to reducing fine lines and wrinkles, the choices can feel overwhelming. As someone who works closely with clients every day at Columbine Aesthetics, I often hear the same question: “What’s the difference between Daxxify, Botox, and Xeomin—and which one lasts the longest?” Each of these FDA-approved injectables softens expression lines and helps restore a smoother, refreshed appearance. But what makes them distinct comes down to formulation, longevity, and how your body responds over time. In this guide, I’ll walk you through what sets Daxxify apart, how it compares to Botox and Xeomin, and how we help you choose the right wrinkle relaxer for your goals.

What Makes Daxxify Different from Botox and Xeomin?

Daxxify is the newest generation of botulinum toxin type A injectables, designed with innovation and longevity in mind. Unlike Botox and Xeomin, which use human or bacterial proteins to stabilize the neurotoxin, Daxxify is powered by Peptide Exchange Technology™. This means it uses a peptide-based stabilizer—no human or animal byproducts—to help the active ingredient bind more effectively to the targeted muscles. This unique formulation enables Daxxify to deliver results lasting six to nine months, compared to the three to four months typically seen with Botox and Xeomin. For many of our clients at Columbine Aesthetics, this means fewer maintenance visits and longer periods of smooth, youthful-looking skin.

How Do Botox and Xeomin Compare?

Botox® remains one of the most trusted names in aesthetics for a reason—it’s effective, predictable, and safe. It works by temporarily relaxing muscle activity in targeted areas like the forehead, crow’s feet, and glabella (frown lines).

Xeomin®, on the other hand, is often described as the “naked neurotoxin” because it contains only the active botulinum toxin molecule—no complexing proteins. This purity can help reduce the risk of developing resistance over time, making Xeomin a strong choice for long-term users or those who’ve noticed diminishing effects with Botox.

All three treatments—Daxxify, Botox, and Xeomin—deliver natural, confident results when administered by experienced injectors. For clients exploring Daxxify as Botox alternative, the appeal often lies in its peptide-based formula and longer-lasting effects, offering a more advanced approach to wrinkle reduction with fewer maintenance sessions. The key difference lies in the longevity of those results and the frequency of touch-ups needed.

Which Injectable Lasts the Longest?

If your main concern is longevity, Daxxify clearly stands out. Clinical studies have shown that its effects can remain visible for up to nine months in some patients—nearly double the duration of traditional neurotoxins.

However, duration can vary based on several factors, including:

• Your metabolism and muscle activity
• The area treated (glabella and forehead often lasts longest)
• Dosage and injection technique
• Lifestyle habits such as exercise and a skincare routine

At Columbine Aesthetics, we personalize each treatment plan to ensure you get the most natural-looking, long-lasting results possible—whether you choose Daxxify, Botox, or Xeomin.

Who Should Consider Daxxify Over Botox or Xeomin?

I often recommend Daxxify to clients who lead busy lifestyles or travel frequently, as it helps them maintain their results with fewer appointments. The extended duration means you can enjoy smoother skin for half a year—or more—without the need for constant upkeep. It’s also ideal for individuals who prefer a low-maintenance, year-round wrinkle reduction plan. On the other hand, if you’re new to injectables or want to start with a more familiar option, Botox or Xeomin can be excellent choices for your first treatment. Our goal at Columbine Aesthetics is to help you make an informed, confident decision that fits your aesthetic goals and comfort level.

Are There Differences in Results or Feel?

All three injectables deliver smooth, natural results when administered properly, but subtle differences do exist.

• Daxxify may offer a slightly firmer, longer-lasting muscle relaxation effect due to its peptide formulation.
• Botox provides consistent, reliable smoothing with a familiar onset and duration.
• Xeomin offers a lightweight feel and may appeal to clients who value minimalist formulations.

Regardless of which product you choose, our injectors take time to understand your facial anatomy, muscle movement, and desired look to ensure every treatment enhances your features naturally—not dramatically.

Why Choose Columbine Aesthetics for Your Injectable Treatments?

At Columbine Aesthetics, you’re not just booking a treatment—you’re gaining a partner in your aesthetic journey. Our Nurse Practitioner-led team combines medical precision with artistry to ensure your results look seamless, balanced, and true to you. We use FDA-approved neurotoxins from trusted brands like Daxxify, Botox®, and Xeomin®, and every session begins with a personalized consultation to determine what will work best for your skin, schedule, and long-term goals.

Many of our clients also choose to combine Daxxify with other treatments such as dermal fillers, microneedling, or skin rejuvenation procedures for enhanced, full-face results. During your consultation, we’ll design a tailored plan that maximizes your outcome—helping you achieve a naturally refreshed, youthful look that lasts.

See Which Injectable Is Right for You – Call Us Today

Whether you’re looking for the longevity of Daxxify or the classic reliability of Botox or Xeomin, we’ll help you make the best choice for your aesthetic goals. Smooth lines, refreshed confidence, and long-lasting results are just a consultation away. Call Columbine Aesthetics today at (720) 504-4407 or schedule your appointment online to discover which wrinkle relaxer fits your lifestyle best.